Whole Body Regeneration - Genetic Switches

Breakthrough Harvard University Research


Source: Stock image of DNA

Salamanders, Geicos, Worms DNA
Harvard scientists started with a simple question:  if some animals can regenerate parts of their bodies and even whole-body regeneration, why can't I?  The findings from their innovative research are astounding.  They've uncovered a number of DNA switches that appear to control genes used in whole body regeneration.  Their research is documented in the journal Science.

3 Banded Panther Worms
Examples of body regeneration,  such as restoration of a severed leg or tail, in the animal kingdom
include salamanders, geicos and worms.  The team used 3 banded panther worms that can regenerate.  Their findings:  a section of non-coding DNA controls the activation of a "master control gene" called early growth response or EGR.  The EGR controls a number of other processes by switching genes on and off.

Tip of the Iceberg
The team says their findings are just the tip of the iceberg of what accounts for regeneration in some animals. But they are the first to document that it starts with a master control gene switching other genes on and off.

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